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This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors; aspirin creates an allosteric change in the structure of the COX enzyme. [2] However, other effects of aspirin, such as uncoupling oxidative phosphorylation in mitochondria, [3] and the modulation of signaling through NF-κB, are ...
Lysine acetylsalicylate, also known as aspirin DL-lysine or lysine aspirin, is a more soluble form of acetylsalicylic acid (aspirin). As with aspirin itself, it is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antithrombotic and antipyretic properties. [ 1 ]
Guiding principles for more ethical use of animals in testing are the Three Rs first described by Russell and Burch in 1959. [41] These principles are now followed in many testing establishments worldwide. Replacement refers to the preferred use of non-animal methods over animal methods whenever it is possible to achieve the same scientific aim.
For some people, aspirin does not have as strong an effect on platelets as for others, an effect known as aspirin-resistance or insensitivity. One study has suggested women are more likely to be resistant than men, [158] and a different, aggregate study of 2,930 people found 28% were resistant. [159]
Vase life is a term used by the floristry industry that describes the period during which a cut flower or cut foliage retains its appearance in a vase. This is a major consideration in identifying plant species suitable for use in floristry, as plants with a long vase life are far more desirable than those with a short vase life.
Ciona intestinalis (sometimes known by the common name of vase tunicate) is an ascidian (sea squirt), a tunicate with very soft tunic. Its Latin name literally means "pillar of intestines", referring to the fact that its body is a soft, translucent column-like structure, resembling a mass of intestines sprouting from a rock. [ 1 ]
Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. [1] The classic symptoms are ringing in the ears , nausea , abdominal pain , and a fast breathing rate . [ 1 ]
2 HC 9 H 7 O 4 + Na 2 CO 3 → 2 NaC 9 H 7 O 4 + CO 2 ↑ + H 2 O. The resulting solution is then filtered to remove any undissolved acetylsalicylic acid and is mixed with a solution containing Cu 2+ cations (copper(II) sulfate is suitable), precipitating bright blue crystals of copper aspirinate immediately. The crystals can then be filtered ...