Search results
Results from the WOW.Com Content Network
Mitragynine toxicity in humans is largely unknown, as animal studies show significant species-specific differences in mitragynine tolerance. [5] Mitragynine toxicity in humans is rarely reported although specific examples of seizures and liver toxicity in kratom consumers have been reported.
An equianalgesic chart can be a useful tool, but the user must take care to correct for all relevant variables such as route of administration, cross tolerance, half-life and the bioavailability of a drug. [5] For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the ...
7-Hydroxymitragynine (7-OH) is a terpenoid indole alkaloid from the plant Mitragyna speciosa, commonly known as kratom. [2] It was first described in 1994 [3] and is a human metabolite metabolized from mitragynine present in the Mitragyna speciosa. 7-OH binds to opioid receptors like mitragynine, but research suggests that 7-OH binds with greater efficacy.
From ancient history to the modern day, the clitoris has been discredited, dismissed and deleted -- and women's pleasure has often been left out of the conversation entirely. Now, an underground art movement led by artist Sophia Wallace is emerging across the globe to challenge the lies, question the myths and rewrite the rules around sex and the female body.
Mitragynine pseudoindoxyl is a μ-opioid receptor agonist and δ-opioid receptor antagonist.It is a G protein biased agonist at the μ-opioid receptor, which may be responsible for its favorable side effect profile compared to conventional opioids. [3]
Dementia impacts millions of older adults, but researchers are still learning how, exactly, to prevent this devastating illness. Now, research suggests that increasing your intake of one specific ...
Tolerogenic DCs present a potential strategy for treatment of autoimmune diseases, allergic diseases and transplant rejections. Moreover, Ag-specific tolerance in humans can be induced in vivo via vaccination with Ag-pulsed ex vivo generated tolerogenic DCs. [5] For that reason, tolerogenic DCs are an important promising therapeutic tool. [6]
Human actions have reduced orangutan habitats by more than 80% over the past 20 years. Deforestation, illegal logging, and mining have been devastating to the ecosystem. Researchers estimate that ...