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Orphenadrine (sold under many brand names) [1] is an anticholinergic drug of the ethanolamine antihistamine class; it is closely related to diphenhydramine. It is a muscle relaxant that is used to treat muscle pain and to help with motor control in Parkinson's disease , but has largely been superseded by newer drugs.
Orphenadrine; Bromazine; Clemastine; Dimenhydrinate; Alkylamines: The isomerism is a significant factor in the activity of the agents in this group. E-triprolidine, for example, is 1000-fold more potent than Z-triprolidine. This difference relates to the positioning and fit of the molecules in the histamine H 1-receptor binding site. [15]
Another class of antispasmodics for such treatment includes cyclobenzaprine, carisoprodol, diazepam, orphenadrine, and tizanidine. [7] Meprobamate is another effective antispasmodic which was first introduced for clinical usage in 1955 mainly as an anxiolytic and soon afterward became a blockbuster psychotropic drug.
Norgesic is the brand name of a muscle relaxant produced by Medicis Pharmaceutical (currently Valeant Pharmaceuticals).The generic is a combination of 385 mg of paracetamol, 25 mg of orphenadrine citrate [1] and 30 mg of caffeine.
Methocarbamol and orphenadrine are each used in more than 250,000 U.S. emergency department visits for lower back pain each year. [22] In the United States, low back pain is the fifth most common reason for all physician visits and the second most common symptomatic reason. [ 23 ]
Women in the third trimester of pregnancy should avoid this drug because there is a risk that naproxen, like other NSAIDs, may cause premature closure of the ductus arteriosus.
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