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The human gallbladder is a hollow grey-blue organ that sits in a shallow depression below the right lobe of the liver. [2] In adults, the gallbladder measures approximately 7 to 10 centimetres (2.8 to 3.9 inches) in length and 4 centimetres (1.6 in) in diameter when fully distended. [3]
In the developed world, 10 to 15% of adults have gallstones. [3] Of those with gallstones, biliary colic occurs in 1 to 4% each year. [3] Nearly 30% of people have further problems related to gallstones in the year following an attack. [3] About 15% of people with biliary colic eventually develop inflammation of the gallbladder if not treated. [3]
Cholelithiasis (gallstones) Can predispose to cholecystitis (gall bladder infections) and ascending cholangitis (biliary tree infection) Can progress to choledocholithiasis (gallstones in the bile duct) and gallstone pancreatitis (inflammation of the pancreas) Gastric calculi can cause colic, obstruction, torsion, and necrosis.
Most people with gallstones (about 80%) are asymptomatic. [ 2 ] [ 3 ] However, when a gallstone obstructs the bile duct and causes acute cholestasis , a reflexive smooth muscle spasm often occurs, resulting in an intense cramp -like visceral pain in the right upper part of the abdomen known as a biliary colic (or "gallbladder attack"). [ 4 ]
The most common cause of bile duct obstruction is when gallstone(s) are dislodged from the gallbladder into the cystic duct or common bile duct resulting in a blockage. A blockage of the gallbladder or cystic duct may cause cholecystitis. If the blockage is beyond the confluence of the pancreatic duct, this may cause gallstone pancreatitis.
Most people with gallstones do not have symptoms. [1] However, when a gallstone temporarily lodges in the cystic duct, they experience biliary colic. [1] Biliary colic is abdominal pain in the right upper quadrant or epigastric region. It is episodic, occurring after eating greasy or fatty foods, and leads to nausea and/or vomiting. [13]
Synthesis of bile acids is a major route of cholesterol metabolism in most species other than humans. The body produces about 800 mg of cholesterol per day and about half of that is used for bile acid synthesis producing 400–600 mg daily. Human adults secrete between 12 and 18 g of bile acids into the intestine each day, mostly after meals.
Alternatively, where a suitable head of water is not available, pumped-storage hydroelectricity or other forms of grid energy storage such as compressed air energy storage and thermal energy storage can store energy developed by high-wind periods and release it when needed. The type of storage needed depends on the wind penetration level ...