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Results are consistent with novelty-seeking behavior being a complex trait associated with many genes, and the variance attributable to DRD4 by itself being very small. The meta-analysis of 11 studies did find that another polymorphism in the gene, the -521C/T, showed an association with novelty seeking. [21]
Dopamine transporter DAT1 and dopamine receptor DRD4 are associated with novelty seeking. [citation needed] Parkinson's patients, who are intrinsically low in dopamine, are found to have low novelty seeking scores. [citation needed] Gene variants that have been investigated are, e.g., 5-HTTLPR in the serotonin transporter gene and gene variants ...
The novelty-seeking trait is considered a heritable tendency of individuals to take risks for the purpose of achieving stimulation and seeking new environments and situations that make their experiences more intense. The trait has been associated with the level of motive and excitement in response to novelty.
Cloninger suggested that the three dimensions, novelty seeking, harm avoidance, and reward dependence, were correlated with low basal dopaminergic activity, high serotonergic activity, and low basal noradrenergic activity, respectively. [5] Much research has gone into examining these links, e.g., with personality genetics.
Cloninger's tridimensional personality theory offers three independent "temperament" dimensions which aid in measuring how different individuals feel or behave. Reward Dependence (RD) is one of the three temperament dimensions, the other two being "Harm Avoidance (HA)" and "Novelty Seeking (NS)". A temperament, according to Cloninger, is the ...
The SNP has been investigated with respect to novelty seeking, — a personality trait that may be measured with the Temperament and Character Inventory. [ 2 ] [ 3 ] A 2008 meta-analysis indicates a possible association between novelty seeking and C-521T though rather small.
Impulsive sensation-seeking: measures low socialisation, and high psychoticism, impulsivity, and sensation-seeking. The impulsivity items assess lack of planfulness and a tendency to act without thinking. The sensation seeking items describe a liking for thrills and excitement, novelty and variety, and unpredictable situations and friends. [3]
A desire to experience novelty. A corresponding and related desire to create novelty. A neophile is distinct from a revolutionary in that anyone might become a revolutionary if pushed far enough by the reigning authorities or social norms, whereas neophiles are revolutionaries by nature. Their intellectual abhorrence of tradition and repetition ...