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The synergy between trimethoprim and sulfamethoxazole was first described in the late 1960s. [25] [26] [27] Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately, because they inhibit successive steps in the folate synthesis pathway. They are given in a one-to-five ratio in their tablet ...
An example of such testing is antibiotic susceptibility testing by measurement of minimum inhibitory concentration which is routinely used in medical microbiology and research. If a suspension used is too heavy or too dilute, an erroneous result (either falsely resistant or falsely susceptible) for any given antimicrobial agent could occur.
In chemistry, a suspension is a heterogeneous mixture of a fluid that contains solid particles sufficiently large for sedimentation. The particles may be visible to the naked eye , usually must be larger than one micrometer , and will eventually settle , although the mixture is only classified as a suspension when and while the particles have ...
Barium sulfate suspension, often simply called barium, is a contrast agent used during X-rays. [1] Specifically it is used to improve visualization of the gastrointestinal tract (esophagus, stomach, intestines) on plain X-ray or computed tomography. [2] It is taken by mouth or used rectally. [3]
A solution to this is using a wetting solution as the liquid vehicle for suspension preparation. [7] Wetting solution increases the dispersal ability of the solid particles by replacing the air film to increase steric hindrance and minimise interactions between solid particles and resulting in a decreased rate of aggregation. [7] [27]
While the MIC is the lowest concentration of an antibacterial or antifungal agent necessary to inhibit visible growth, the minimum bactericidal concentration (MBC) is the minimum concentration of an antibacterial agent that results in bacterial death. It is defined by the inability to re-culture bacteria, and the closer the MIC is to the MBC ...
The biological activity of a pesticide, be it chemical or biological in nature, is determined by its active ingredient (AI - also called the active substance). Pesticide products very rarely consist of the pure active ingredient.
Sulfamethoxazole inhibits dihydropteroate synthase, an enzyme involved further upstream in the same pathway. [24] Trimethoprim and sulfamethoxazole are commonly used in combination due to possible synergistic effects, and reduced development of resistance. [24] This benefit has been questioned. [26] Tetrahydrofolate synthesis pathway