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Sulfasalazine metabolizes to sulfapyridine. Serum levels should be monitored every three months, and more frequently at the outset. Serum levels above 50 μg/L are associated with side effects. In rare cases, sulfasalazine can cause severe depression in young males. It can also cause oligospermia and temporary infertility.
Sulfapyridine levels above 50 μg/L are associated with the side-effects. Patients on high dose sulfasalazine require folic supplementation (1 mg/day) (1000 μg/day) to maintain normal cell division. This may, however, be counter-productive for patients who are also taking methotrexate, which is a folic acid inhibitor.
Inflammation is the body's natural defense mechanism to protect and heal itself. When you stub your toe or catch a cold, your body kicks into gear with inflammation to begin the healing process.
Combinations of DMARDs are often used, because each drug in the combination can be used in a smaller dose than if it were given alone, thus reducing the risk of side effects. [citation needed] Many patients receive an NSAID and at least one DMARD, sometimes with low-dose oral glucocorticoids. If disease remission is observed, regular NSAIDs or ...
These NSAIDs, while reducing inflammation, also inhibit platelet aggregation and increase the risk of gastrointestinal ulcers and bleeds. [11] COX-2 selective inhibitors have fewer gastrointestinal side effects, but promote thrombosis, and some of these agents substantially increase the risk of heart attack.
Sulfasalazine; Mesalazine (5-Aminosalicylic acid) Side effects may include abdominal pain, diarrhea, headaches, and nausea. [1] References This page was last edited ...
Out of all the mashed potato mistakes you can make, adding too much liquid to your spuds is sure to ruin your day. After all, nobody wants to take a scoop of soupy mashed potatoes! But what if you ...
Newer analogous compounds prevent this complication because they have a lower pK a, around 5–6, [citation needed] making them more likely to remain in a soluble form. Many thousands of molecules containing the sulfanilamide structure have been created since its discovery (by one account, over 5,400 permutations by 1945), yielding improved ...
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261