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Oogenesis (/ ˌ oʊ. ə ˈ dʒ ɛ n ɪ s ɪ s /) or ovogenesis is the differentiation of the ovum (egg cell) into a cell competent to further develop when fertilized. [1] It is developed from the primary oocyte by maturation.
During the primary oocyte stage of oogenesis, the nucleus is called a germinal vesicle. [2] The only normal human type of secondary oocyte has the 23rd (sex) chromosome as 23,X (female-determining), whereas sperm can have 23,X (female-determining) or 23,Y (male-determining).
During oogenesis, meiosis arrests twice. The main arrest occurs during the diplotene stage of prophase 1, this arrest lasts until puberty. The second meiotic arrest then occurs after ovulation during metaphase 2 and lasts for a much shorter time than the first arrest.
In oogenesis, it doesn't really have any significance in itself, since it is very similar to the ovum. However, it fills the purpose as the female counterpart of the male spermatid in spermatogenesis. Each chromosome is split between the two ootids, leaving only one chromatid per chromosome. Thus, there are 23 chromatids in total (1N).
During oogenesis, the oogonia become primary oocytes. Oocytes (immature ova) residing in the primordial follicle of the ovary are in a non-growing prophase arrested state, but have the capacity to undergo highly efficient homologous recombinational repair of DNA damages including double-strand breaks. [ 1 ]
A polar body is a small haploid cell that is formed at the same time as an egg cell during oogenesis, but generally does not have the ability to be fertilized. It is named from its polar position in the egg. When certain diploid cells in animals undergo cytokinesis after meiosis to produce egg cells, they sometimes divide unevenly.
Asymmetric division is a process of mitosis in which one oogonium divides unequally to produce one daughter cell that will eventually become an oocyte through the process of oogenesis, and one daughter cell that is an identical oogonium to the parent cell. This occurs during the 15th week to the 7th month of embryonic development. [2]
Maternal effect genes [11] are expressed during oogenesis by the mother (expressed prior to fertilization) and develop the anterior-posterior and dorsal ventral polarity of the egg. The anterior end of the egg becomes the head; posterior end becomes the tail. the dorsal side is on the top; the ventral side is in underneath.