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Ranitidine has 10% of the affinity that cimetidine has to CYP450, so it causes fewer side effects, but other H 2 blockers famotidine and nizatidine have no CYP450 significant interactions. [131] Ranitidine was introduced in 1981, and was the world's biggest-selling prescription drug by 1987.
Cimetidine is widely distributed throughout all tissues. [7] It is able to cross the blood–brain barrier and can produce effects in the central nervous system (e.g., headaches, dizziness, somnolence). [2] The volume of distribution of cimetidine is 0.8 L/kg in adults and 1.2 to 2.1 L/kg in children. [6]
H2 antagonists, sometimes referred to as H2RAs[1] and also called H2 blockers, are a class of medications that block the action of histamine at the histamine H 2 receptors of the parietal cells in the stomach. This decreases the production of stomach acid. H 2 antagonists can be used in the treatment of dyspepsia, peptic ulcers and ...
CHICAGO (Reuters) -A jury in Chicago on Thursday rejected an Illinois woman’s claim that the now discontinued heartburn drug Zantac caused her colon cancer, in the first trial out of thousands ...
Some tests showed that Zantac's active ingredient, ranitidine, could degrade into NDMA over time or when exposed to heat. The U.S. Food and Drug Administration asked manufacturers to pull the drug ...
April 30, 2024 at 6:46 PM. By Brendan Pierson. (Reuters) -The first trial over claims that blockbuster heartburn drug Zantac, once sold by GSK and other companies, causes cancer is set to begin ...