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SM-102 is a synthetic amino lipid which is used in combination with other lipids to form lipid nanoparticles. [1] These are used for the delivery of mRNA-based vaccines, [2][3][4] and in particular SM-102 forms part of the drug delivery system for the Moderna COVID-19 vaccine. [5][6][7] Lipid nanoparticles are an extension of earlier RNA ...
Vaccine Excipients Adenovirus vaccine: This list refers to the type 4 and type 7 adenovirus vaccine tablets licensed in the US: Acetone, alcohol, anhydrous lactose, castor oil, cellulose acetate phthalate, dextrose, D-fructose, D-mannose, FD&C Yellow #6 aluminium lake dye, fetal bovine serum, human serum albumin, magnesium stearate, micro crystalline cellulose, plasdone C, Polacrilin potassium ...
Vaccine ingredients. A vaccine dose contains many ingredients (stabilizers, adjuvants, residual inactivating ingredients, residual cell culture materials, residual antibiotics and preservatives) very little of which is the active ingredient, the immunogen. A single dose may have merely nanograms of virus particles, or micrograms of bacterial ...
A lipid nanoparticle is typically spherical with an average diameter between 10 and 1000 nanometers. Solid lipid nanoparticles possess a solid lipid core matrix that can solubilize lipophilic molecules. The lipid core is stabilized by surfactants (emulsifiers). The emulsifier used depends on administration routes and is more limited for ...
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Inorganic nanoparticles of alum, [60] silica and clay, as well as organic nanoparticles based on polymers and lipids, are very popular adjuvants within modern vaccine formulations. [61] Nanoparticles of natural polymers such as chitosan are useful for vaccine development due to their biocompatibility and biodegradability. [62]
A nanoparticle or ultrafine particle is a particle of matter 1 to 100 nanometres (nm) in diameter. [1][2] The term is sometimes used for larger particles, up to 500 nm, or fibers and tubes that are less than 100 nm in only two directions. [2]: 394 At the lowest range, metal particles smaller than 1 nm are usually called atom clusters instead.
Immunologic adjuvant. In immunology, an adjuvant is a substance that increases or modulates the immune response to a vaccine. [1] The word "adjuvant" comes from the Latin word adiuvare, meaning to help or aid. "An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune responses when ...
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