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SM-102 is a synthetic amino lipid which is used in combination with other lipids to form lipid nanoparticles. [1] These are used for the delivery of mRNA-based vaccines, [2][3][4] and in particular SM-102 forms part of the drug delivery system for the Moderna COVID-19 vaccine. [5][6][7] Lipid nanoparticles are an extension of earlier RNA ...
A DNA vaccine is a type of vaccine that transfects a specific antigen -coding DNA sequence into the cells of an organism as a mechanism to induce an immune response. [1][2] DNA vaccines work by injecting genetically engineered plasmid containing the DNA sequence encoding the antigen (s) against which an immune response is sought, so the cells ...
Liposome. Scheme of a liposome formed by phospholipids in an aqueous solution. Liposomes are composite structures made of phospholipids and may contain small amounts of other molecules. Though liposomes can vary in size from low micrometer range to tens of micrometers, unilamellar liposomes, as pictured here, are typically in the lower size ...
IC41 is a peptide vaccine candidate against the Hepatitis C virus. It consists of five synthetic peptides along with the synthetic adjuvant called poly-l-arginine. [13] Multimeric-001 is the most efficient peptide vaccine candidate against influenza. It contains B- and T-cell epitopes from Hemagglutinin.
Hemagglutinin (influenza) Influenza hemagglutinin (HA) or haemagglutinin[p] (British English) is a homotrimeric glycoprotein found on the surface of influenza viruses and is integral to its infectivity. Hemagglutinin is a Class I Fusion Protein, having multifunctional activity as both an attachment factor and membrane fusion protein.
Cationic liposome. Cationic liposomes are spherical structures that contain positively charged lipids. Cationic liposomes can vary in size between 40 nm and 500 nm, and they can either have one lipid bilayer (monolamellar) or multiple lipid bilayers (multilamellar). [1] The positive charge of the phospholipids allows cationic liposomes to form ...
A nanoparticle–biomolecule conjugate is a nanoparticle with biomolecules attached to its surface. Nanoparticles are minuscule particles, typically measured in nanometers (nm), that are used in nanobiotechnology to explore the functions of biomolecules. Properties of the ultrafine particles are characterized by the components on their surfaces ...
mRNA in vitro transcription, innate and adaptive immunity activation. An mRNAvaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. [ 1 ] The vaccine delivers molecules of antigen -encoding mRNA into cells, which use the designed mRNA as a blueprint to build foreign protein that ...