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P2Y 12 is a chemoreceptor for adenosine diphosphate (ADP) [5] [6] that belongs to the G i class of a group of G protein-coupled (GPCR) purinergic receptors. [7] This P2Y receptor family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides .
P2Y 12 structure as generated by PYMOL with color-coded helices. P2Y receptors are membrane proteins belonging to the class A family of G protein-coupled receptors (GPCRs). [5] [6] P2Y receptor proteins display large-scale structural domains typical of GPCRs, consisting of seven hydrophobic transmembrane helices connected by three short extracellular loops and three variably sized ...
P2Y12 receptors further amplify the response to ADP and draw forth the completion of aggregation. ADP in the blood is converted to adenosine by the action of ecto-ADPases , inhibiting further platelet activation via adenosine receptors .
"High school physics textbooks" (PDF). Reports on high school physics. American Institute of Physics; Zitzewitz, Paul W. (2005). Physics: principles and problems. New York: Glencoe/McGraw-Hill. ISBN 978-0078458132
These analogues had very short half-life due to retention of the triphosphate groups and thus needed to be given IV. Modification of these analogues led to the discovery of ticagrelor, a selective and stable non-phosphate P2Y 12 receptor antagonist. [9] Ticagrelor belongs to the class of cyclopentyl-triazolopyrimidine (CPTP). [10]
Symbol Meaning SI unit of measure magnetic vector potential: tesla meter (T⋅m) : area: square meter (m 2) : amplitude: meter: atomic mass number: unitless acceleration: meter per second squared (m/s 2)
Continuous charge distribution. The volume charge density ρ is the amount of charge per unit volume (cube), surface charge density σ is amount per unit surface area (circle) with outward unit normal nĚ‚, d is the dipole moment between two point charges, the volume density of these is the polarization density P.
Ticagrelor (Brilinta) is often listed with thienopyridine inhibitors and has similar indications for use but is not a thienopyridine. It is a cyclo-pentyltriazolo-pyrimidine that is distinct from the mechanism of the thienopyridines in that it reversibly (rather than irreversibly) inhibits the P2Y 12 receptor.