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Amoeboid movement is the most typical mode of locomotion in adherent eukaryotic cells. [1] It is a crawling-like type of movement accomplished by protrusion of cytoplasm of the cell involving the formation of pseudopodia ("false-feet") and posterior uropods. One or more pseudopodia may be produced at a time depending on the organism, but all ...
Neutrophils extravasate from blood vessels to the site of tissue injury or infection during the innate immune response.. In immunology, leukocyte extravasation (also commonly known as leukocyte adhesion cascade or diapedesis – the passage of cells through the intact vessel wall) is the movement of leukocytes (white blood cells) out of the circulatory system (extravasation) and towards the ...
These two movement types are highly plastic and can convert to each other, depending on the extracellular matrix type and intracellular regulation. [1] The collective–amoeboid transition (CMT) is a process by which collective multicellular groups dissociate into amoeboid single cells following the down-regulation of integrins.
Like the amoeboid movement of leukocytes, nuclei inside single migrating tumor cells move forward toward the leading edge. [ 2 ] In contrast to the mesenchymal movement, amoeboid or a non-proteolytic model of migration prevails when the surrounding matrix is characterized by relatively low stiffness ("soft" matrix).
Microfilament functions include cytokinesis, amoeboid movement, cell motility, changes in cell shape, endocytosis and exocytosis, cell contractility, and mechanical stability. Microfilaments are flexible and relatively strong, resisting buckling by multi-piconewton compressive forces and filament fracture by nanonewton tensile forces.
A common example of this type of amoeboid cell is the macrophage. They are also essential to amoeboid-like locomotion. Human mesenchymal stem cells are a good example of this function: these migratory cells are responsible for in-utero remodeling; for example, in the formation of the trilaminar germ disc during gastrulation. [13]
In anatomy and histology, the term wandering cell (or ameboid cell) [1] is used to describe cells that are found in connective tissue, but are not fixed in place.This term is used occasionally and usually refers to blood leukocytes (which are not fixed and organized in solid tissue) in particular mononuclear phagocytes.
Similarly to some of the white blood cells of vertebrates, in many species amebocytes are found in the blood or body fluid (e.g. as the blood cells of Limulus, the horseshoe crab) [1] and play a role in the defense of the organism against pathogens. Depending on the species, an amebocyte may also digest and distribute food, dispose of wastes ...