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Sca-1 stands for "Stem cells antigen-1" (official gene symbol: Ly6a). It consist of 18-kDa mouse glycosyl phosphatidylinositol-anchored cell surface protein (GPI-AP) of the LY6 gene family. [1] It is the common biological marker used to identify hematopoietic stem cell (HSC) along with other markers.
KSL cells in cell biology are an early form of mouse/murine hematopoietic stem cells.Characteristics are Kit (+), Sca-1 (+) and Lin (-). HSCs [Hematopoietic stem cells] in murine cultures show phenotypic markers as being CD34-, CD150+, and Flt3- for LTR [long-term reconstitution].
[17]: 177–188 Using harvested stem cells in stem cell therapies require immunosuppression to prevent the host from rejecting the transplants; creating induced pluripotent stem cells from the host's own cells would mitigate this risk and has had some testing in other neurodegenerative diseases. [17]: 177–188
The cell surface antigens most commonly used to identify hES cells are the glycolipids stage specific embryonic antigen 3 and 4, and the keratan sulfate antigens Tra-1-60 and Tra-1-81. The molecular definition of a stem cell includes many more proteins and continues to be a topic of research. [29]
The definition of hematopoietic stem cell has developed since they were first discovered in 1961. [5] The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. Hematopoietic stem cells constitute 1:10,000 of cells in myeloid tissue.
A stem cell possesses two properties: . Self-renewal is the ability to go through numerous cycles of cell division while still maintaining its undifferentiated state. Stem cells can replicate several times and can result in the formation of two stem cells, one stem cell more differentiated than the other, or two differentiated cells.
Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells.Stem cells can also be identified by functional assays. Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that do the same. [1]
17311 Ensembl ENSG00000049130 ENSMUSG00000019966 UniProt P21583 P20826 RefSeq (mRNA) NM_003994 NM_000899 NM_013598 NM_001347156 RefSeq (protein) NP_000890 NP_003985 NP_001334085 NP_038626 Location (UCSC) Chr 12: 88.49 – 88.58 Mb Chr 10: 99.85 – 99.94 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine ...