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Reference ranges (reference intervals) for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples. Reference ranges for blood tests are studied within the field of clinical chemistry (also known as "clinical biochemistry", "chemical pathology" or "pure blood chemistry"), the ...
Reference ranges for blood pressure Stage Approximate age Systolic Diastolic Range Typical example Range Typical example Infants 1 to 12 months: 75-100 [33] 85: 50–70 [33] 60 Toddlers 1 to 4 years: 80-110 [33] 95: 50–80 [33] 65 Preschoolers 3 to 5 years: 80-110 [33] 95: 50–80 [33] 65 School age 6 to 13 years: 85-120 [33] 100: 55–80 [33 ...
Some of the biochemical diagnostic tests used include salivary and blood serum cortisol testing, 24-hour urinary free cortisol (UFC) testing, the dexamethasone suppression test (DST). No single test is perfect and multiple tests should always be used to achieve a proper diagnosis. [8]
The long test uses 1 mg tetracosactide (intramuscular). Blood is taken 1, 4, 8, and 24 hours later. Normal plasma cortisol level should reach 1,000 nmol/L by 4 hours. In primary Addison's disease, the cortisol level is reduced at all stages, whereas in secondary corticoadrenal insufficiency, a delayed but normal response is seen.
Alternative causes of Cushing's should be excluded with imaging of lungs, adrenal glands, and pituitary gland; these often appear normal in Cushing's; In the alcoholic patient with pseudo-Cushing's, admission to hospital (and avoidance of alcohol) will result in normal midnight cortisol levels within five days, excluding Cushing's [6]
The secretion also loses its normal diurnal pattern of morning peak levels and evening and night time troughs. [12] Nevertheless, secretion remains pulsatile and there is a marked variation in blood samples from the same individual. [13] High blood levels of cortisol during critical illness could theoretically be protective because of several ...
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However, in humans, cortisol is the primary glucocorticoid that is produced primarily in the zona fasciculata of the adrenal cortex. Corticosterone has only weak glucocorticoid and mineralocorticoid potencies in humans and is important mainly as an intermediate in the steroidogenic pathway from pregnenolone to aldosterone.
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