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Core residues are often conserved in a protein family, whereas the residues in loops are less conserved, unless they are involved in the protein's function. Protein tertiary structure can be divided into four main classes based on the secondary structural content of the domain. [25] All-α domains have a domain core built exclusively from α ...
Nucleosome core particles are observed when chromatin in interphase is treated to cause the chromatin to unfold partially. The resulting image, via an electron microscope, is "beads on a string". The string is the DNA, while each bead in the nucleosome is a core particle. The nucleosome core particle is composed of DNA and histone proteins. [29]
The B2 RNA is a small noncoding RNA polymerase III transcript that represses mRNA transcription in response to heat shock in mouse cells. B2 RNA inhibits transcription by binding to core Pol II. Through this interaction, B2 RNA assembles into preinitiation complexes at the promoter and blocks RNA synthesis. [40]
Given an ideal I in a commutative ring R and an R-module M, the direct sum = / + is a graded module over the associated graded ring / +. A morphism f : N → M {\displaystyle f:N\to M} of graded modules, called a graded morphism or graded homomorphism , is a homomorphism of the underlying modules that respects grading; i.e., f ( N i ) ⊆ M ...