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In June 2010, denosumab was approved by the FDA for use in postmenopausal women with risk of osteoporosis [26] under the brand name Prolia, [27] and in November 2010 as Xgeva for the prevention of skeleton-related events in people with bone metastases from solid tumors. [28] Denosumab is the first RANKL inhibitor to be approved by the FDA. [26]
Zoledronic acid, also known as zoledronate and sold under the brand name Zometa among others, [ 7] by Novartis among others, is a medication used to treat a number of bone diseases. [ 3] These include osteoporosis, high blood calcium due to cancer, bone breakdown due to cancer, Paget's disease of bone [ 3] and Duchenne muscular dystrophy (DMD).
Strontium ranelate is registered as a prescription drug in more than 70 countries for the treatment of post-menopausal osteoporosis to reduce the risk of vertebral and hip fractures. In the United States, strontium ranelate is not approved by the FDA.
Romosozumab, sold under the brand name Evenity, is a medication used to treat osteoporosis. [ 7][ 8] It has been found to decrease the risk of fractures of the spine. [ 7] Common side effects include headache, joint pain, and injection site reactions including pain. [ 7] It may increase the risk of heart attacks, strokes, and deaths from ...
The drug is one of only two treatments that help to promote bone formation, and the first to reduce bone loss at the same time. First osteoporosis drug of its kind for more than a decade approved ...
Teriparatide was approved for medical use in the United States in 1987. [13] [26] Teriparatide (Forteo) was approved by the FDA in November 2002, for the treatment of osteoporosis in men and postmenopausal women who are at high risk for having a fracture. [27]
Clodronic acid or clodronate disodium (Na 2 CH 2 Cl 2 O 6 P 2) is a first generation (non-nitrogenous) bisphosphonate.It is an anti-osteoporotic drug approved for the prevention and treatment of osteoporosis in post-menopausal women and men to reduce vertebral fractures, hyperparathyroidism, hypercalcemia in malignancy, multiple myeloma and fracture related pain because of its anti ...
Most experts agree that these drugs would need to be studied more extensively for each potential indication in order to safely prescribe them outside of their FDA-approved usages, which is ...
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