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Skin cancers are cancers that arise from the skin. They are due to the development of abnormal cells that have the ability to invade or spread to other parts of the body. [ 10] Skin cancer is the most commonly diagnosed form of cancer in humans. [ 11][ 12][ 13] There are three main types of skin cancers: basal-cell skin cancer (BCC), squamous ...
Cutaneous squamous-cell carcinoma is the second-most common cancer of the skin (after basal-cell carcinoma, but more common than melanoma). It usually occurs in areas exposed to the sun. Sunlight exposure and immunosuppression are risk factors for SCC of the skin, with chronic sun exposure being the strongest environmental risk factor. [26]
Melanoma is the most dangerous type of skin cancer; it develops from the melanin-producing cells known as melanocytes. [1] It typically occurs in the skin, but may rarely occur in the mouth, intestines, or eye (uveal melanoma). [1] [2] In women, melanomas most commonly occur on the legs; while in men, on the back. [2]
Keratinocyte. Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. In humans, they constitute 90% of epidermal skin cells. [ 1] Basal cells in the basal layer ( stratum basale) of the skin are sometimes referred to as basal keratinocytes. [ 2] Keratinocytes form a barrier against environmental ...
The human skin is the outer covering of the body and is the largest organ of the integumentary system. The skin has up to seven layers of ectodermal tissue guarding muscles, bones, ligaments and internal organs. Human skin is similar to most of the other mammals ' skin, and it is very similar to pig skin. Though nearly all human skin is covered ...
Merkel cell carcinoma ( MCC) is a rare and aggressive skin cancer occurring in about three people per million members of the population. [ 1] It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. [ 2]
Melanocytes are melanin -producing neural crest -derived [ 3] cells located in the bottom layer (the stratum basale) of the skin's epidermis, the middle layer of the eye (the uvea ), [ 4] the inner ear, [ 5] vaginal epithelium, [ 6] meninges, [ 7] bones, [ 8] and heart found in many mammals and birds. [ 9] Melanin is a dark pigment primarily ...
Scale forms on the skin surface in various disease settings, and is the result of abnormal desquamation. In pathologic desquamation, such as that seen in X-linked ichthyosis, the stratum corneum becomes thicker (hyperkeratosis), imparting a "dry" or scaly appearance to the skin, and instead of detaching as single cells, corneocytes are shed in clusters, which forms visible scales. [2]