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Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Without sexual stimulation and no activation of the NO/cGMP system, sildenafil should not cause an erection. Studies in vitro have shown that sildenafil is selective for PDE5. [ 21 ] Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9 ...
Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and increased ...
Sildenafil — does this by inhibiting an enzyme referred to as phosphodiesterase type 5, or PDE5. The PDE5 enzyme helps control blood flow to your privates. PDE5 normally breaks down cGMP, which ...
According to the Food and Drug Administration (FDA), it usually takes 30 to 60 minutes for Viagra or generic sildenafil to start producing a noticeable improvement in your climax quality.
Sildenafil is most commonly prescribed to be taken one time per day in doses between 25 and 100 mg for ED. Your healthcare provider will determine the best dosage for you based on a number of factors.
Sildenafil was initially introduced for clinical trial in 1989. It was the result of extensive research on chemical agents targeting PDE5 that could be effective in treatment of coronary heart disease. [22] Sildenafil did not prove effective for coronary heart disease but an interesting side effect was discovered, a penile erection.
Phosphodiesterase type 5 is an enzyme that’s found in the smooth muscle cells of blood vessels and helps regulate blood flow. When you take sildenafil, it stops PDE5 from working properly.
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