Ad
related to: sildenafil cgmp 5 000goodrx.com has been visited by 100K+ users in the past month
109 S High St #100, Columbus, OH · Directions · (614) 224-4261
- Our Social Impact Mission
At GoodRx, values matter. Visit us
to see how we make a difference.
- Research You Can Rely On
Our team works hard to provide you
with the latest healthcare info.
- Do I Need Insurance?
No! Compare Our Prices to Your
Insurance & Get the Biggest Savings
- Find A Pharmacy Near Me
Search & Compare the Lowest Prices
to Save at Your Favorite Pharmacy
- Our Social Impact Mission
Search results
Results from the WOW.Com Content Network
Sildenafil — does this by inhibiting an enzyme referred to as phosphodiesterase type 5, or PDE5. The PDE5 enzyme helps control blood flow to your privates. PDE5 normally breaks down cGMP, which ...
Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and increased ...
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Sildenafil was initially introduced for clinical trial in 1989. It was the result of extensive research on chemical agents targeting PDE5 that could be effective in treatment of coronary heart disease. [22] Sildenafil did not prove effective for coronary heart disease but an interesting side effect was discovered, a penile erection.
Sildenafil can still be used to treat hypertension, but today, the primary use of this PDE5 inhibitor is to remedy ED. Other first-line treatment options for blood pressure and heart disease are ...
Viagra (or sildenafil) lasts three to five hours after it’s consumed. Cialis (tadalafil) has a half-life of 17.5 hours, meaning this drug lasts up to 36 hours after it’s consumed.
According to the Food and Drug Administration (FDA), it usually takes 30 to 60 minutes for Viagra or generic sildenafil to start producing a noticeable improvement in your climax quality.
Without sexual stimulation and no activation of the NO/cGMP system, sildenafil should not cause an erection. Studies in vitro have shown that sildenafil is selective for PDE5. [ 21 ] Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9 ...
Ad
related to: sildenafil cgmp 5 000goodrx.com has been visited by 100K+ users in the past month
109 S High St #100, Columbus, OH · Directions · (614) 224-4261