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Rhinovirus A and B use "major" ICAM-1 (Inter-Cellular Adhesion Molecule 1), also known as CD54 (Cluster of Differentiation 54), on respiratory epithelial cells, as receptors to bind to. Some subgroups under A and B uses the "minor" LDL receptor instead. [18] Rhinovirus C uses cadherin-related family member 3 (CDHR3) to mediate cellular entry. [19]
An estimated 22–189 million school days are missed annually due to a cold. As a result, parents missed 126 million workdays to stay home to care for their children. When added to the 150 million workdays missed by employees who have a cold, the total economic impact of cold-related work loss exceeds $20 billion per year.
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Unlike all other enteroviruses, EV-D68 displays acid lability and a lower optimum growth temperature, both characteristic features of the human rhinoviruses. It was previously called human rhinovirus 87 by some researchers. [5] Since the year 2000, the original virus strains diversified and evolved a genetically distinct outbreak strain, clade B1.
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In 2022, the rate of new pneumonia cases in Sedgwick County was double the rate for cases across Kansas.
Human rhinovirus internal cis-acting regulatory element (CRE) is a CRE from the human rhinoviruses. The CRE is located within the genome segment encoding the capsid proteins so is found in a protein coding region.
The Menendez brothers murdered their parents, José and Kitty, on the evening of Aug. 20, 1989, in their Beverly Hills home. Each armed with a 12-gauge shotgun, Lyle, then 21, and Erik, then 18 ...