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The mammalian target of rapamycin (mTOR), [5] also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. [6] [7] [8] mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein ...
This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus). It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor.
FK506 binding protein 5, also known as FKBP5, is a protein which in humans is encoded by the FKBP5 gene. [5] Function. ... (FK506) and sirolimus (rapamycin).
FKBP (FKBP1A) does not normally form a dimer but will dimerize in the presence of FK1012, a derivative of the drug tacrolimus (FK506). This has made it a useful tool for chemically induced dimerization applications where it can be used to manipulate protein localization, signalling pathways and protein activation.
This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform.
Rapamycin was the first known inhibitor of mTORC1, considering that mTORC1 was discovered as being the target of rapamycin. [83] Rapamycin will bind to cytosolic FKBP12 and act as a scaffold molecule, allowing this protein to dock on the FRB regulatory region (FKBP12-Rapamycin Binding region/domain) on mTORC1. [84]
FK506 binding protein 6, also known as FKBP6, is a human gene. The encoded protein shows structural homology to FKBP immunophilins, which bind to the immunosuppressants FK506 and rapamycin. FKBP6 is essential for homologous chromosome pairing in meiosis during spermatogenesis. Targeted inactivation of FKBP6 in mice results in infertile males ...
2287 30795 Ensembl ENSG00000100442 ENSMUSG00000020949 UniProt Q00688 Q62446 RefSeq (mRNA) NM_002013 NM_013902 RefSeq (protein) NP_002004 NP_038930 Location (UCSC) Chr 14: 45.12 – 45.14 Mb Chr 12: 65.11 – 65.12 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse FK506-binding protein 3 also known as FKBP25 is a protein that in humans is encoded by the FKBP3 gene. Function The protein ...
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