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  2. Amyloid plaques - Wikipedia

    en.wikipedia.org/wiki/Amyloid_plaques

    Dietmar Thal and his colleagues have proposed a sequence of stages of plaque formation in the brains of Alzheimer patients [34] [35] In Phase 1, plaques appear in the neocortex; in Phase 2, they appear in the allocortex, hippocampal formation and amygdala; in Phase 3, the basal ganglia and diencephalon are affected; in Phase 4, plaques appear ...

  3. Cardiac amyloidosis - Wikipedia

    en.wikipedia.org/wiki/Cardiac_amyloidosis

    Symptoms of cardiac amyloidosis are a combination of heart failure and amyloid deposition in various other organs. [2] Amyloid deposition in the heart causes restrictive diastolic heart failure that progresses to systolic heart failure. [8] Cardiac manifestations include: Dyspnea on exertion [2] Peripheral edema and ascites [2] Pericardial ...

  4. Amyloid cardiomyopathy - Wikipedia

    en.wikipedia.org/wiki/Amyloid_cardiomyopathy

    Amyloid cardiomyopathy (stiff heart syndrome) [5] is a condition resulting in the death of part of the myocardium (heart muscle). It is associated with the systemic production and release of many amyloidogenic proteins , especially immunoglobulin light chain or transthyretin (TTR). [ 6 ]

  5. Atherosclerosis: What Men Need to Know About Plaque ... - AOL

    www.aol.com/atherosclerosis-men-know-plaque...

    A heart attack occurs suddenly when an atherosclerotic plaque in one of the arteries to your heart ruptures. It can cause symptoms such as: Chest pain, pressure, or tightness

  6. Amyloid - Wikipedia

    en.wikipedia.org/wiki/Amyloid

    To date, 37 human proteins have been found to form amyloid in pathology and be associated with well-defined diseases. [2] The International Society of Amyloidosis classifies amyloid fibrils and their associated diseases based upon associated proteins (for example ATTR is the group of diseases and associated fibrils formed by TTR). [3]

  7. Familial amyloid cardiomyopathy - Wikipedia

    en.wikipedia.org/wiki/Familial_amyloid_cardiomyo...

    Greater than 40% of these patients present with carpal tunnel syndrome before developing ATTR-CM. Cardiac involvement is often identified with the presence of conduction system disease ( sinus node or atrioventricular node dysfunction) and/or congestive heart failure , including shortness of breath, peripheral edema , syncope , exertional ...

  8. P3 peptide - Wikipedia

    en.wikipedia.org/wiki/P3_peptide

    p3 peptide also known as amyloid β- peptide (Aβ) 17–40/42 is the peptide resulting from the α-and γ-secretase cleavage from the amyloid precursor protein ().It is known to be the major constituent of diffuse plaques observed in Alzheimer's disease (AD) brains and pre-amyloid plaques in people affected by Down syndrome.

  9. Amyloid beta - Wikipedia

    en.wikipedia.org/wiki/Amyloid_beta

    Amyloid beta (Aβ, Abeta or beta-amyloid) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol ...

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