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In the pharmaceutical industry, drug dissolution testing is routinely used to provide critical in vitro drug release information for both quality control purposes, i.e., to assess batch-to-batch consistency of solid oral dosage forms such as tablets, and drug development, i.e., to predict in vivo drug release profiles. [1]
Tablet hardness testing is a laboratory technique used by the pharmaceutical industry to determine the breaking point and structural integrity of a tablet and find out how it changes "under conditions of storage, transportation, packaging and handling before usage" [1] The breaking point of a tablet is based on its shape. [2]
A tablet is usually a compressed preparation that contains: 5-10% of the drug (active substance); 80% of fillers, disintegrants, lubricants, glidants, and binders; and; 10% of compounds which ensure easy disintegration, disaggregation, and dissolution of the tablet in the stomach or the intestine.
Metal testing is a process or procedure used to check composition of an unknown metallic substance. [1] There are destructive processes and nondestructive processes. Metal testing can also include, determining the properties of newly forged metal alloys .
Work hardening occurs most notably for ductile materials such as metals. Ductility is the ability of a material to undergo plastic deformations before fracture (for example, bending a steel rod until it finally breaks). The tensile test is widely used to study deformation mechanisms. This is because under compression, most materials will ...
The physical properties of a tablet are tested either by manual or automated sampling and IPC testing (in-process control). Tablet "hardness", also called "breaking force", is tested to assure that the tablet's strength will survive all further processes, such as dedusting, coating and packaging.
I think it would make the article clearer if "dissolution" was explained. CBHA 03:22, 10 May 2013 (UTC) [] @CBHA: A good suggestion but I disagree. Dissolution testing is a common name used in the Pharma industry, it should be pretty self-evident to most readers what dissolution means even if your not sure or don't work in that field ( a simple Google search can rectify any doubts).
The situation is further complicated in dynamic systems where deformation and recrystallization occur simultaneously. As a result, it has generally proven impossible to produce an accurate predictive model for industrial processes without resorting to extensive empirical testing.