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Loop diuretics are 90% bonded to proteins and are secreted into the proximal convoluted tubule through organic anion transporter 1 (OAT-1), OAT-2, and ABCC4.Loop diuretics act on the Na +-K +-2Cl − symporter (NKCC2) in the thick ascending limb of the loop of Henle to inhibit sodium, chloride and potassium reabsorption.
A diuretic (/ ˌ d aɪ j ʊ ˈ r ɛ t ɪ k /) is any substance that promotes diuresis, the increased production of urine. This includes forced diuresis. A diuretic tablet is sometimes colloquially called a water tablet. There are several categories of diuretics. All diuretics increase the excretion of water from the body, through the kidneys ...
The thiazide diuretics also deplete circulating potassium unless combined with a potassium-sparing diuretic or supplemental potassium. Some authors have challenged thiazides as first line treatment. [55] [56] [57] However, as the Merck Manual of Geriatrics notes, "thiazide-type diuretics are especially safe and effective in the elderly." [58]
β-blockers, of which atenolol is mainly studied, provides weaker protection against stroke and mortality in patients over 60 years old compared to other antihypertensive medications. [ 24 ] [ 25 ] [ 26 ] [ 18 ] Diuretics may be associated with better cardiovascular and cerebrovascular outcomes than β-blockers in the elderly.
The first of the best weight-loss diets for seniors is the Mediterranean diet.This eating plan is all about consuming whole foods like fruits, veggies, whole grains, nuts, seeds, beans, and olive oil.
Windstar Cruises is one of the best senior cruises for travelers seeking an intimate experience. With small, luxury cruise ships accommodating between 148 and 342 guests and a crew-to-guest ratio ...
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