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  2. Ibuprofen - Wikipedia

    en.wikipedia.org/wiki/Ibuprofen

    Common side effects include heartburn, nausea, indigestion, and abdominal pain. [8] As with other NSAIDs, potential side effects include gastrointestinal bleeding. [10] Long-term use has been associated with kidney failure, and rarely liver failure, and it can exacerbate the condition of patients with heart failure. [8]

  3. Nonsteroidal anti-inflammatory drug - Wikipedia

    en.wikipedia.org/wiki/Nonsteroidal_anti...

    These differential effects are due to the different roles and tissue localisations of each COX isoenzyme. [11] By inhibiting physiological COX activity, NSAIDs may cause deleterious effects on kidney function, [12] and, perhaps as a result of water and sodium retention and decreases in renal blood flow, may lead to heart problems. [13]

  4. Analgesic nephropathy - Wikipedia

    en.wikipedia.org/wiki/Analgesic_nephropathy

    Proper kidney function depends upon adequate blood flow to the kidney. Kidney blood flow is a complex, tightly regulated process that relies on a number of hormones and other small molecules, such as prostaglandins. Under normal circumstances, prostaglandin E2 (PGE 2) produced by the kidney is necessary to support adequate blood flow to the kidney.

  5. Pain management in children - Wikipedia

    en.wikipedia.org/wiki/Pain_management_in_children

    Children can develop opioid tolerance, where larger doses are needed to have the same effect. Tolerance occurs earlier in children than in adults, especially with prolonged use. [49] When tolerance to opioids develop, it takes a larger dose of the opioid to achieve the same analgesic effect. [50] Non-pharmacological treatments have few side ...

  6. National drug stores limit sale of children’s medicine amid ...

    www.aol.com/news/childrens-tylenol-motrin...

    Amid surges of RSV, flu and COVID-19, some parents are having a tough time finding children's medications like Tylenol and Motrin. Experts share tips to help.

  7. Hepatotoxicity - Wikipedia

    en.wikipedia.org/wiki/Hepatotoxicity

    Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.

  8. Paracetamol - Wikipedia

    en.wikipedia.org/wiki/Paracetamol

    Compared to Ibuprofen—which can have adverse effects that include diarrhea, vomiting, and abdominal pain—paracetamol is well tolerated with fewer side effects. [89] Prolonged daily use may cause kidney or liver damage.

  9. Paracetamol poisoning - Wikipedia

    en.wikipedia.org/wiki/Paracetamol_poisoning

    The increasing liver damage also changes biochemical markers of liver function; International normalized ratio (INR) and the liver transaminases ALT and AST rise to abnormal levels. [14] Acute kidney failure may also occur during this phase, typically caused by either hepatorenal syndrome or multiple organ dysfunction syndrome. In some cases ...

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