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Paget's disease may affect any one or several bones of the body (most commonly pelvis, tibia, femur, lumbar vertebrae, and skull), but never the entire skeleton, [1] [2] [3] and does not spread from bone to bone. [4] Rarely, a bone affected by Paget's disease can transform into a malignant bone cancer.
There are many bone disorders such as osteoporosis, Paget's disease, hypothyroidism. [2] Although there are many forms of bone disorders, they all have one thing in common; abnormalities of specific organs involved, deficiency in vitamin D or low Calcium in diet, which results in poor bone mineralization .
Other causes of bone diseases include severe impacts/injuries and weakness in bones/bone loss. The effects of bone disorders will vary with disease. The effects can occur physically, mentally and financially as well as impact the individuals quality of life. Orthopaedic disorders can drastically affect an individual's functional ability ...
Platybasia is a spinal disease of a malformed relationship between the occipital bone and cervical spine. It may be caused by Paget's disease. Platybasia is also a feature of Gorlin-Goltz syndrome, commonly known as basal cell nevus syndrome. It may be developmental in origin or due to softening of the skull base bone, allowing it to be pushed ...
Leprosy, Paget's disease of bone Leonine facies is a facies that resembles that of a lion . It is seen in multiple conditions and has been classically described for lepromatous leprosy as well as Paget's disease of bone .
Leontiasis ossea, also known as leontiasis, lion face or lion face syndrome, is a rare medical condition, characterized by an overgrowth of the facial and cranial bones. It is not a disease in itself, but a symptom of other diseases, including Paget's disease, fibrous dysplasia, hyperparathyroidism and renal osteodystrophy. [citation needed]
Multisystem proteinopathy (MSP) is a dominantly inherited, pleiotropic, degenerative disorder of humans that can affect muscle, bone, and/or the central nervous system.MSP can manifest clinically as classical amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), inclusion body myopathy (IBM), Paget's disease of bone (PDB), or as a combination of these disorders. [1]
Paget's disease of bone: unaffected ... Osteoporosis can affect nearly 1 in 3 women and the bone loss is the most rapid within the first 2–3 years after menopause ...