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Neuroleptic malignant syndrome (NMS) is a rare [5] [6] but life-threatening reaction that can occur in response to antipsychotics (neuroleptic) or other drugs that block the effects of dopamine. [ 1 ] [ 7 ] Symptoms include high fever , confusion, rigid muscles, variable blood pressure, sweating, and fast heart rate. [ 1 ]
The headquarters of the NMS is located at 4-12 Nsamizi Road, in Entebbe, [4] a city on the northern shores of Lake Victoria, approximately 34 kilometres (21 mi), southwest of Kampala, the capital and its largest city. [5] The coordinates of the head office are 0°03'49.0"N, 32°28'13.0"E (Latitude:0.063611; Longitude:32.470278). [6]
Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene. [5]ATG13 is an autophagy factor required for phagosome formation. . ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through phosphorylation of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 comp
Autophagy protein 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on chromosome 6.It is an E3 ubi autophagic cell death.ATG5 is a key protein involved in the extension of the phagophoric membrane in autophagic vesicles.
Proteins that are degraded by chaperone-assisted selective autophagy include pathogenic forms of the Huntingtin protein, which cause Huntington's disease. [4] Furthermore, the expression of the cochaperone BAG3 is upregulated in aged neuronal cells, which correlates with an increased necessity to dispose oxidatively damaged proteins through autophagy. [3]
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Autophagy related 7 is a protein in humans encoded by ATG7 gene. [5] [6] Related to GSA7; APG7L; APG7-LIKE.[6]ATG 7, present in both plant and animal genomes, acts as an essential protein for cell degradation and its recycling.
Nitrogen mustards (NMs) are cytotoxic organic compounds with the bis(2-chloroethyl)amino ((ClC 2 H 4) 2 NR) functional group. [1] Although originally produced as chemical warfare agents, [ 2 ] [ 3 ] they were the first chemotherapeutic agents for treatment of cancer. [ 4 ]