Search results
Results from the WOW.Com Content Network
The T state has a lower affinity for oxygen than the R state, so with increased acidity, the hemoglobin binds less O 2 for a given P O2 (and more H +). This is known as the Bohr effect . [ 4 ] A reduction in the total binding capacity of hemoglobin to oxygen (i.e. shifting the curve down, not just to the right) due to reduced pH is called the ...
A test statistic shares some of the same qualities of a descriptive statistic, and many statistics can be used as both test statistics and descriptive statistics. However, a test statistic is specifically intended for use in statistical testing, whereas the main quality of a descriptive statistic is that it is easily interpretable. Some ...
Most frequently, t statistics are used in Student's t-tests, a form of statistical hypothesis testing, and in the computation of certain confidence intervals. The key property of the t statistic is that it is a pivotal quantity – while defined in terms of the sample mean, its sampling distribution does not depend on the population parameters, and thus it can be used regardless of what these ...
The t-test p-value for the difference in means, and the regression p-value for the slope, are both 0.00805. The methods give identical results. This example shows that, for the special case of a simple linear regression where there is a single x-variable that has values 0 and 1, the t-test gives the same results as the linear regression. The ...
For example, the test statistic might follow a Student's t distribution with known degrees of freedom, or a normal distribution with known mean and variance. Select a significance level (α), the maximum acceptable false positive rate. Common values are 5% and 1%. Compute from the observations the observed value t obs of the test statistic T.
The Bohr effect favors the T state rather than the R state. (shifts the O 2-saturation curve to the right). Conversely, when the carbon dioxide levels in the blood decrease (i.e., in the lung capillaries), carbon dioxide and protons are released from hemoglobin, increasing the oxygen affinity of the protein.
The Student's t distribution plays a role in a number of widely used statistical analyses, including Student's t test for assessing the statistical significance of the difference between two sample means, the construction of confidence intervals for the difference between two population means, and in linear regression analysis.
In the R state, the ionic pairings are absent, meaning that the R state's stability increases when the pH increases, as these residues are less likely to stay protonated in a more basic environment. The Bohr effect works by simultaneously destabilizing the high-affinity R state and stabilizing the low-affinity T state, which leads to an overall ...