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In 1817, English physician James Parkinson published the first full medical description of the disease as a neurological syndrome in his monograph An Essay on the Shaking Palsy. [ 246 ] [ 247 ] He presented six clinical cases, including three he had observed on the streets near Hoxton Square in London . [ 248 ]
The history of Parkinson's disease expands from 1817, when British apothecary James Parkinson published An Essay on the Shaking Palsy, to modern times. Before Parkinson's descriptions, others had already described features of the disease that would bear his name, while the 20th century greatly improved knowledge of the disease and its ...
James Parkinson FGS (11 April 1755 – 21 December 1824) [1] was an English surgeon, apothecary, geologist, palaeontologist and political activist. He is best known for his 1817 work An Essay on the Shaking Palsy, [2] in which he was the first to describe "paralysis agitans", a condition that would later be renamed Parkinson's disease by Jean-Martin Charcot.
Parkinsonism is a clinical syndrome characterized by the four motor symptoms found in Parkinson's disease: tremor, bradykinesia (slowed movements), rigidity, and postural instability. [1] [2] Parkinsonism gait problems can lead to falls and serious physical injuries. Other common symptoms include:
Parkinson's Disease causes constipation and gastric dysmotility that is severe enough to endanger comfort and even health. [26] A factor in this is the appearance of Lewy bodies and Lewy neurites even before these affect the functioning of the substantia nigra in the neurons in the enteric nervous system that control gut functions.
While many environmental factors may exacerbate Parkinson's disease, exercise is considered to be one of the main protective factors for neurodegenerative disorders, including Parkinson's disease. The types of exercise interventions that have been studied can be categorized as either aerobic or goal-based. [ 47 ]
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