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Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. [11] It is administered by intravenous injection. [11] There is also an albumin-bound formulation. [11]
Chemicals extracted from clippings of Taxus brevifolia (Pacific yew) have been used as the basis for two chemotherapy drugs, docetaxel and paclitaxel. [8] Euphorbia peplus. Contains ingenol mebutate (Picato) which is used to treat skin cancer [9] Maytenus ovatus
Paclitaxel total synthesis in organic chemistry is a major ongoing research effort in the total synthesis of paclitaxel (Taxol). [1] This diterpenoid is an important drug in the treatment of cancer but, also expensive because the compound is harvested from a scarce resource, namely the Pacific yew ( Taxus brevifolia ).
Paclitaxel was originally derived from the Pacific yew tree. [4] [5] Taxanes are difficult to synthesize because of their numerous chiral centres—taxol has 11 of these. Recently, the presence of taxanes in the shells and leaves of Corylus avellana (the common hazel plant) has been reported. [6] [7]
The chemotherapy drug paclitaxel (taxol), used in breast, ovarian, and lung cancer treatment, can be derived from T. brevifolia [28] and other species of yew. As it was already becoming scarce when its chemotherapeutic potential was realized around the 1990s, the Pacific yew was never commercially harvested from its habitat at a large scale ...
Holton Taxol total synthesis overview from raw material perspective. The Holton Taxol total synthesis, published by Robert A. Holton and his group at Florida State University in 1994, was the first total synthesis of Taxol (generic name: paclitaxel). [1] [2] The Holton Taxol total synthesis is a good example of a linear synthesis.
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SAR of paclitaxel analogous. Paclitaxel has achieved great success as an anti-cancer drug, yet there has been continuous effort to improve its efficacy and develop analogues which are more active and have greater bioavailability and specificity. The importance of C-13 substituted phenylisoserine side chain to bioactivity of paclitaxel has been ...
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