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Loop diuretics are pharmacological agents that primarily inhibit the Na-K-Cl cotransporter located on the luminal membrane of cells along the thick ascending limb of the loop of Henle. [4] They are often used for the treatment of hypertension and edema secondary to congestive heart failure , liver cirrhosis , or chronic kidney disease .
Azosemide is a high-ceiling loop diuretic agent that was brought to market in 1981 by Boehringer Mannheim. [1] [2] As of 2015 it was available as a generic in some Asian countries. [3] Azosemide has been found as an adulterant in ketamine. [4]
Bumetanide is a loop diuretic and works by decreasing the reabsorption of sodium by the kidneys. The main difference between bumetanide and furosemide is in their bioavailability and potency. About 60% of furosemide is absorbed in the intestine, and there are substantial inter- and intraindividual differences in bioavailability (range 10-90%).
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The tendency, as for all loop diuretics, to cause low serum potassium concentration (hypokalemia) has given rise to combination products, either with potassium or with the potassium-sparing diuretic amiloride (Co-amilofruse). Other electrolyte abnormalities that can result from furosemide use include hyponatremia, hypochloremia, hypomagnesemia ...
The Centers for Disease Control and Prevention (CDC) says to aim for: 150 minutes (or 2.5 hours) of moderate-intensity activity spread over the course of a week Or 75 minutes of vigorous-intensity ...
A Canadian woman was arrested after trying to smuggle over 20 pounds of methamphetamine through a New Zealand airport, authorities said. The illicit drugs were disguised as Christmas presents, New ...
The flu is surging in New York and across the US — and claimed the lives of five kids in the days before Christmas.. Positive tests climbed a whopping 12% for the week ending Dec. 21, according ...