Search results
Results from the WOW.Com Content Network
Her research program revealed a genetic variation in the human catechol-O-methyltransferase gene with pain sensitivity and the risk of chronic pain conditions (Hum. Mol. Genet., 2004; Science, 2006), individual differences in responses to analgesic drugs being driven by genetics (Hum. Mol. Genet., 2009; Pain, 2020), and the protective role of ...
This gene is normally switched on during the development of pain-sensing nerve cells. People with homozygous mutations of the PRDM12 gene experience congenital insensitivity to pain (CIP). [5] [6] PRMD12 is a part of a larger domain that mediate histone methyltransferases. Enzymes target gene promoters in order to control gene expression. [7]
Gene Disease Database; Gene Expression Omnibus (GEO [9]): a public functional genomics data repository from the U.S. National Cancer Institute (NCI), which supports array- and sequence-based data. Tools for querying and downloading gene expression profiles are provided.
The background indicates the symbol sources: HGNC Approved Genes, EntrezGene Database, Ensembl Gene Database, or GeneCards Generated Genes. Aliases: Aliases, as its name indicates, shows synonyms and aliases of the gene according to diverse sources such as HGNC. The right column displays how the aliases associated with the resources and gives ...
KEGG (Kyoto Encyclopedia of Genes and Genomes) is a collection of databases dealing with genomes, biological pathways, diseases, drugs, and chemical substances.KEGG is utilized for bioinformatics research and education, including data analysis in genomics, metagenomics, metabolomics and other omics studies, modeling and simulation in systems biology, and translational research in drug development.
NCBI provides the Gene database, Online Mendelian Inheritance in Man, the Molecular Modeling Database (3D protein structures), dbSNP (a database of single-nucleotide polymorphisms), the Reference Sequence Collection, a map of the human genome, and a taxonomy browser, and coordinates with the National Cancer Institute to provide the Cancer ...
Tail flick test apparatus. The tail flick test is a test of the pain response in animals, similar to the hot plate test.It is used in basic pain research and to measure the effectiveness of analgesics, by observing the reaction to heat.
In bioinformatics, a Gene Disease Database is a systematized collection of data, typically structured to model aspects of reality, in a way to comprehend the underlying mechanisms of complex diseases, by understanding multiple composite interactions between phenotype-genotype relationships and gene-disease mechanisms. [1]