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Diatchenko also believes in and contributes to open science to advance our understanding of the molecular mechanisms of pain. Her lab's Human Pain Genetics Database (HPGdb) summarizes all extant data on the genetic contributors of pain and the Transcriptomics Pain Signatures Database (PSGS) summarizes all available data on genome-wide ...
This gene is normally switched on during the development of pain-sensing nerve cells. People with homozygous mutations of the PRDM12 gene experience congenital insensitivity to pain (CIP). [5] [6] PRMD12 is a part of a larger domain that mediate histone methyltransferases. Enzymes target gene promoters in order to control gene expression. [7]
The human Proteinpedia is based on HPRD (Human protein reference database)which is a repository hosting over 30,000 human proteins. However it is unclear how many of these are unique proteins Human Protein Atlas: The Swedish Government It contains roughly 10 million IHC images of a bit less than 25,000 antibodies.
Congenital insensitivity to pain (CIP), also known as congenital analgesia, is one or more extraordinarily rare conditions in which a person cannot feel (and has never felt) physical pain. [1] The conditions described here are separate from the HSAN group of disorders, which have more specific signs and cause.
Furthermore, Na v 1.8-null mice failed to produce action potentials, indicating that Na v 1.8 is essential to the perception of pain in cold temperatures. [19] Although the early studies on the biophysics of Na V 1.8 channels were carried out in rodent channels, more recent studies have examined the properties of human Na V 1.8 channels.
He is known for his work in the genetics of pain, [2] for being among the first scientists to demonstrate sex differences in pain perception, [3] and for identifying previously unknown factors and confounds that affect the integrity of contemporary pain research. [4] He has an h-index of 100. [5]
Familial episodic pain syndrome, also known simply as FEPS, is a group of rare genetic peripheral neuropathies which are characterized by recurrent random episodes of intense pain which occur most often in the upper or lower parts of the body occurring in several members of the same family.
[1] [5] [6] The GeneCards database provides access to free Web resources about more than 350,000 known and predicted human genes, integrated from >150 data resources, such as HGNC, Ensembl, and NCBI. The core gene list is based on NCBI, Ensembl and approved gene symbols published by the HUGO Gene Nomenclature Committee (HGNC).