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BRCA-related breast cancer appears at an earlier age than sporadic breast cancer. [9]: 89–111 It has been asserted that BRCA-related breast cancer is more aggressive than normal breast cancer, however most studies in specific populations suggest little or no difference in survival rates despite seemingly worse prognostic factors.
Triple-negative breast cancer comprises 15–20% of all breast cancer cases [3] and affects more young women or women with a mutation in the BRCA1 gene than other breast cancers. [4] Triple-negative breast cancers comprise a very heterogeneous group of cancers. TNBC is the most challenging breast cancer type to treat. [5]
The chromosomal location of BRCA1 was discovered by Mary-Claire King's team at UC Berkeley in 1990. [21] After an international race to refine the precise location of BRCA1, [22] the gene was cloned in 1994 by scientists at University of Utah, National Institute of Environmental Health Sciences (NIEHS) and Myriad Genetics.
While the BRCA gene, known as the "breast cancer gene," is only found in 1 in 400 people and accounts for between 5 to 10 percent of breast cancer cases and 15 percent of ovarian cancer cases, ...
For people with a BRCA1 mutation, guidelines recommend routine breast imaging to detect early signs of breast cancer beginning at age 25. Screening may start sooner for people with a family member ...
"Whether or not the harms of risk assessment, counseling, testing, and interventions outweigh the benefits depends on a woman's individual risk profile and family history," Dr. Douglas K. Owens ...
Histologic factors associated with worse prognosis include high histologic grade, hormone receptor negativity, and HER2 negativity. Regarding genetic risk factors, BRCA1-associated breast cancers may have higher rates of lung and brain metastases but a lower rate of bone metastases.
Home genetic test kits from 23andMe may detect some important BRCA gene mutations that can increase your risk for breast cancer. Here's what to know before you test.
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