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There are also MKPs that belong to a group called Atypical MKPs. For example, Vaccina H1-related (VHR) is an atypical MKP because it only has the DUSP region. [28] VHR is only found in lymphoid and hematopoietic cells, and it inactivates the ERK1/2 and JNKs in T-cell receptors. [29] VHR also induces cell cycle arrest. [30] [31]
Mitogen-activated protein Kinase Phosphatases (MKPs) MKPs form a rather large family, with some 11 well-characterized members. They are responsible for the dephosphorylation of active mitogen-activated protein kinases (MAPKs). In accordance with this role, several (but not all) MKPs contain an additional, N-terminal domain.
Mucopolysaccharidosis is a group of metabolic disorders caused by the absence or malfunctioning of lysosomal enzymes.
A very conserved family of dedicated phosphatases is the so-called MAP kinase phosphatases (MKPs), a subgroup of dual-specificity phosphatases (DUSPs). [7] As their name implies, these enzymes are capable of hydrolyzing the phosphate from both phosphotyrosine and the phosphothreonine residues.
DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK, JNK, and p38 with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25-like (CH2) domain. MAPK activation cascades mediate ...
Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene. [5] [6] [7] [8]The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis.
Mucopolysaccharidosis type I is a spectrum of diseases in the mucopolysaccharidosis family. It results in the buildup of glycosaminoglycans (or GAGs, or mucopolysaccharides) due to a deficiency of alpha-L iduronidase, an enzyme responsible for the degradation of GAGs in lysosomes.
63953 Ensembl n/a ENSMUSG00000039384 UniProt Q9Y6W6 Q9ESS0 RefSeq (mRNA) NM_007207 NM_144728 NM_144729 NM_022019 RefSeq (protein) NP_009138 NP_071302 Location (UCSC) n/a Chr 1: 183.75 – 183.81 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene. Dual specificity protein phosphatases ...