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Infantile digital fibromatosis (IDF), also termed inclusion body fibromatosis or Reye's tumor, usually occurs as a single, small, asymptomatic, nodule in the dermis on a finger or toe [1] of infants and young children. [2] IMF is a rare disorder with approximately 200 cases reported in the medical literature as of 2021. [3]
Infantile myofibromatosis: solitary tumors commonly occurring in the head and neck regions; multiple tumors occurring in the skin, subcutaneous tissue, muscles, and/or less commonly bones; or, rarely, tumors occurring in an internal organ(s). [4] Aponeurotic fibroma; Infantile digital fibromatosis; Aggressive infantile fibromatosis
Similarities among bland spindle-cell lesions lead to a large number of possibilities in diagnosis, including fibroblastic sarcomas, Gardner fibroma, scar tissue or keloids, superficial fibromatosis, nodular fasciitis, myofibroma, collagenous fibroma, gastrointestinal stromal tumor, solitary fibrous tumor, phyllodes tumor, and other conditions ...
The fibroma cavernosum or angiofibroma, consists of many often dilated vessels, it is a vasoactive tumor occurring almost exclusively in adolescent males. The cystic fibroma (fibroma cysticum) has central softening or dilated lymphatic vessels. The myxofibroma (fibroma myxomatodes) is produced by liquefaction of the underlying soft tissue.
IMF tumors are usually painless, well-encapsulated, rubbery to hard, and freely movable-to-fixed masses. [8] They may be evident at birth in up to 60% of cases [4] but generally go undetected until they [9] are diagnosed in the first year of life, [8] uncommonly in older infants and young (<10 years/old) children, [4] or rarely in older children and adults (one individual was diagnosed with ...
Dermal dendrocytoma, [1] Dermatofibroma, [2] Fibrous dermatofibroma, [2] Fibrous histiocytoma, [2] Fibroma simplex, [1] Nodular subepidermal fibrosis, [1] and Sclerosing hemangioma [1]) Histopathology of dermatofibroma, with basilar hyperpigmentation of the overlying epidermis (top right), and spindled fibroblasts with collagen entrapment.
Nuchal fibroma [22] Superficial acral fibromyxoma, also termed acral fibromyxoma. [15] Gardner fibroma, a benign proliferation of thick, irregularly arranged collagen bundles with interspersed fibroblasts often association with the genetic disease of familial adenomatous polyposis [23] and its variant, the Gardner's syndrome. [24
Diffuse infantile fibromatosis is a rare condition affecting infants during the first three years of life. This condition is a multicentric infiltration of muscle fibers with fibroblasts resembling those seen in aponeurotic fibromas, presenting as lesions and tumors confined usually to the muscles of the arms, neck, and shoulder area [1]: 607 Diffuse infantile fibromatosis is characterized by ...