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Telmisartan has a carboxylic acid at the 2-position of the biphenyl-methyl group and is more potent than the tetrazole analogue. [ 1 ] It has been reported that imidazoles that have hydroxymethyl and carboxy groups at the 4- and 5 position, possessed potent antagonistic activity, caused by the hydrogen bonding and hydrophilicity of the ...
Telmisartan, sold under the brand name Micardis among others, is a medication used to treat high blood pressure and heart failure. [ 3 ] [ 6 ] It is a reasonable initial treatment for high blood pressure. [ 6 ]
Year of discovery Name of the drug Active ingredients 1st millennium BC: Hyoscyamus niger: Tropane alkaloids (e.g. hyoscyamine and scopolamine). [16] 600 B.C. Glycerol, produced: Glycerol [citation needed] 300 B.C. Opium: Phenanthrenes (e.g. morphine, codeine, and thebaine). [17] Morphine binds to and activates Mu opioid receptors and is analgesic.
The timeline begins at the Bronze Age, as it is difficult to give even estimates for the timing of events prior to this, such as of the discovery of counting, natural numbers and arithmetic. To avoid overlap with timeline of historic inventions , the timeline does not list examples of documentation for manufactured substances and devices unless ...
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of captopril, the first ACE inhibitor. When the adverse effects of captopril became apparent new derivates were designed.
The wrecks of the Titanic and the Titan sit on the ocean floor, separated by 1,600 feet (490 meters) and 111 years of history. The Polar Prince, a Canadian icebreaker ship, steamed out of ...
In the fields of medicine, biotechnology, and pharmacology, drug discovery is the process by which new candidate medications are discovered. [ 1 ] Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery, as with penicillin .
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