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In cell biology, the spindle apparatus is the cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter cells. It is referred to as the mitotic spindle during mitosis , a process that produces genetically identical daughter cells, or the meiotic spindle during meiosis , a process ...
Microtubule and tubulin metrics [1]. Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules can be as long as 50 micrometres, as wide as 23 to 27 nm [2] and have an inner diameter between 11 and 15 nm. [3]
A microtubular membrane is a type of membrane made up of small tubular structures. Microtubular associated membranes are found in various cell types and are essential for maintaining cell structure and function.
The central spindle is a microtubule based structure, which forms in between segregating chromosomes during anaphase where the two sets of microtubules, emanating from opposite halves of the cell, overlap, and become arranged into antiparallel bundles by various microtubule associated proteins (MAPs) and motor proteins.
Astral microtubules anchor the spindle poles to the cell membrane. Microtubule polymerization is nucleated at the microtubule organizing center . An aster is a cellular structure shaped like a star , consisting of a centrosome and its associated microtubules during the early stages of mitosis in an animal cell.
Eukaryotic cells have a variety of internal membrane-bound structures, called organelles, and a cytoskeleton which defines the cell's organization and shape. The nucleus stores the cell's DNA , which is divided into linear bundles called chromosomes ; [ 19 ] these are separated into two matching sets by a microtubular spindle during nuclear ...
Spindle neuron, also known as a von Economo neuron In general medicine, a spindle cell may refer to the spindle -shaped cells that are found in certain types of tumor: Inflammatory fibroid polyp
The most interesting thing was that vinblastine and vincristine, were found to lower the number of white cells in blood. A high number of white cells in the blood indicates leukemia, so a new anti-cancer drug had been discovered. These two alkaloids bind to tubulin to prevent the cell from making the spindles that it needs to be able to divide.