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  2. Norepinephrine - Wikipedia

    en.wikipedia.org/wiki/Norepinephrine

    The general function of norepinephrine is to mobilize the brain and body for action. Norepinephrine release is lowest during sleep, rises during wakefulness, and reaches much higher levels during situations of stress or danger, in the so-called fight-or-flight response. In the brain, norepinephrine increases arousal and alertness, promotes ...

  3. Selective norepinephrine reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Selective_norepinephrine...

    The norepinephrine transporter (NET) serves as the fundamental mechanism for the inactivation of noradrenergic signaling because of the NET termination in the reuptake of norepinephrine (NE). The selectivity and mechanism of action for the NRI drugs remain mostly unresolved and, to date, only a limited number of NRI-selective inhibitors are ...

  4. Norepinephrine (medication) - Wikipedia

    en.wikipedia.org/wiki/Norepinephrine_(medication)

    Norepinephrine, also known as noradrenaline and sold under the brand name Levophed among others, is a medication used to treat people with very low blood pressure. [2] It is the typical medication used in sepsis if low blood pressure does not improve following intravenous fluids . [ 3 ]

  5. Adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Adrenergic_receptor

    Agonist action Mechanism Agonists Antagonists; α 1: A, B, D [a] Norepinephrine > epinephrine >> isoprenaline [9] Smooth muscle contraction, mydriasis, vasoconstriction in the skin, mucosa and abdominal viscera & sphincter contraction of the GI tract and urinary bladder: G q: phospholipase C (PLC) activated, IP 3, and DAG, rise in calcium [7 ...

  6. Alpha-2 adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Alpha-2_adrenergic_receptor

    The α 2-adrenergic receptor binds both norepinephrine released by sympathetic postganglionic fibers and epinephrine (adrenaline) released by the adrenal medulla, binding norepinephrine with slightly higher affinity. [4] It has several general functions in common with the α 1-adrenergic receptor, but also has specific effects of its own.

  7. Sympathomimetic drug - Wikipedia

    en.wikipedia.org/wiki/Sympathomimetic_drug

    The mechanisms of sympathomimetic drugs can be direct-acting (direct interaction between drug and receptor), such as α-adrenergic agonists, β-adrenergic agonists, and dopaminergic agonists; or indirect-acting (interaction not between drug and receptor), such as MAOIs, COMT inhibitors, release stimulants, and reuptake inhibitors that increase the levels of endogenous catecholamines.

  8. Norepinephrine reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Norepinephrine_reuptake...

    Norepinephrine Epinephrine. A norepinephrine reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrine transporter (NET).

  9. Norepinephrine releasing agent - Wikipedia

    en.wikipedia.org/wiki/Norepinephrine_releasing_agent

    A norepinephrine releasing agent (NRA), also known as an adrenergic releasing agent, is a catecholaminergic type of drug that induces the release of norepinephrine (noradrenaline) and epinephrine (adrenaline) from the pre-synaptic neuron into the synapse.