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Sacubitril is a prodrug that is activated to sacubitrilat (LBQ657) by de-ethylation via esterases. [2] Sacubitrilat inhibits the enzyme neprilysin, [3] which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure–lowering peptides that work mainly by reducing blood volume. [4]
Evidence suggests that a reduction of blood pressure by 5 mmHg can decrease the risk of stroke by 34% and of ischaemic heart disease by 21%. It can reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. [2] There are many classes of antihypertensives, which lower blood pressure by different means.
Potential side effects include angioedema, nephrotoxicity, and low blood pressure. [10] It was approved for medical use in the United States and in the European Union in 2015, [11] [12] [13] [7] and in Australia in 2016. [1] In 2022, it was the 165th most commonly prescribed medication in the United States, with more than 3 million prescriptions.
Diuretics, which lower blood pressure directly by causing the kidney to produce more urine. Beta-blockers, which slow down the heart and reduce the force of its contractions.
High blood pressure is caused by the force of blood flow in the arteries being too high. The DASH diet includes heart-healthy foods that lower blood pressure.
Taking medications like blood pressure and lipid-lowering drugs for more than 5 years is associated with a lower incidence of dementia, a new study has found.
Valsartan, sold under the brand name Diovan among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. [8] It belongs to a class of medications referred to as angiotensin II receptor blockers (ARBs). It is a reasonable initial treatment for high blood pressure. [8] It is taken by mouth. [8]
The first-of-its-kind trial randomly assigned 100 adults with obesity and high blood pressure to a treatment regimen of either bariatric surgery and blood pressure medications, or blood pressure ...
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