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Nicotine is a secondary metabolite produced in a variety of plants in the family Solanaceae, most notably in tobacco Nicotiana tabacum, where it can be found at high concentrations of 0.5 to 7.5%. [178] Nicotine is also found in the leaves of other tobacco species, such as Nicotiana rustica (in amounts of 2–14%).
The LD 50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5–1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children. [19] [20] However the widely used human LD 50 estimate of 0.5–1.0 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses; the 2013 review suggests that the lower limit causing fatal ...
Nicotine replacement products vary in the time it takes for the nicotine to enter the body and the total time nicotine stays in the body. [19] The more quickly a dose of nicotine is delivered and absorbed, the higher the addiction risk. [50] It is possible to become dependent on some NRTs. [51]
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Nicotine may result in adverse effects to the neurological growth of the fetus. [65] Nicotine can lead to vasoconstriction of uteroplacental vessels, which reduces the delivery of both nutrients and oxygen to the fetus. As a result, nutrition is re-distributed to prioritize vital organs, such as the heart and the brain, at the cost of less ...
Then there’s the fact that "nicotine, even in small doses, has a high potential for addiction" and that "nicotine's stimulating effects can be habit-forming," says Vinjamoori.
Furthermore, nicotine is absorbed by the body to different degrees depending on the pH level of the product, which is known as the free nicotine or unionized nicotine level. [ citation needed ] Below are some measured nicotine levels of various smokeless tobacco products from 2006 and 2007 and their corresponding free nicotine levels as ...
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