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An applied example is a synthesis of sunitinib begins by mixing 5-fluoroisatin slowly into hydrazine hydrate. [9] After 4 hours at 110 °C, the indole ring structure has been broken into (2-amino-5-fluoro-phenyl)-acetic acid hydrazide with reduction of the ketone at the 3-position.
Piperonal can be prepared by the oxidative cleavage of isosafrole or by using a multistep sequence from catechol or 1,2-methylenedioxybenzene.Synthesis from the latter chemical is accomplished through a condensation reaction with glyoxylic acid followed by cleaving the resulting α-hydroxy acid with an oxidizing agent.
The synthesis of the 1,2,4-triazole has a wide range of biological functions. [ citation needed ] 1,2,4-triazoles have antibacterial , antifungal, antidepressant and hypoglycemic properties. 3-benzylsulfanyl derivates of the triazole also show slight to moderate antimycobacterial activity, but are considered moderately toxic.
Transfer hydrogenation usually occurs at mild temperature and pressure conditions using organic or organometallic catalysts, many of which are chiral, allowing efficient asymmetric synthesis. It uses hydrogen donor compounds such as formic acid , isopropanol or dihydroanthracene , dehydrogenating them to CO 2 , acetone , or anthracene ...
Thiosemicarbazide is the chemical compound with the formula H 2 NC(S)NHNH 2.A white, odorless solid, it is related to thiourea (H 2 NC(S)NH 2) by the insertion of an NH center.. They are commonly used as ligands for transition metal
An infusion basically involves steeping fruit, spices, or any other solid food product in a liquid — in this case, alcohol — so it absorbs the flavors in the food, explains Neil Grosscup, CEO ...
The Shapiro reaction or tosylhydrazone decomposition is an organic reaction in which a ketone or aldehyde is converted to an alkene through an intermediate hydrazone in the presence of 2 equivalents of organolithium reagent.
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