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Mammals are unable to synthesize omega−3 fatty acids, but can obtain the shorter-chain omega−3 fatty acid ALA (18 carbons and 3 double bonds) through diet and use it to form the more important long-chain omega−3 fatty acids, EPA (20 carbons and 5 double bonds) and then from EPA, the most crucial, DHA (22 carbons and 6 double bonds). [2]
There are three types of omega-3 fatty acids; namely alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). [68] Alpha-linoleic acid is an essential fatty acid, and is the form that is most common and widespread of the omega-3 fatty acids.
The omega (ω) end of the chain is at carbon 18, and the double bond closest to the omega carbon begins at carbon 15 = 18−3. Hence, ALA is a ω−3 fatty acid with ω = 18. The terms ω−3 ("omega−3") fatty acid and n−3 fatty acid are derived from the nomenclature of organic chemistry.
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Omega-3 fatty acids have anti-inflammatory properties and therefore need to be supplemented in a closer ratio to omega-6's which are more inflammatory. [33] Out of all of the omega-3 fatty acids that could be used, the most potent are found in fish oil in the forms of EPA and DHA , these have the highest immunomodulatory activities. [ 33 ]
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