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PDE5 inhibitor drugs are effective in men regardless of why they have erectile dysfunction — including vascular disease, nerve problems, and even psychological causes. [citation needed] PDE5-inhibiting drugs can cause a number of side-effects, including headache, lightheadedness, dizziness, flushing, nasal congestion, and changes in vision.
Cyclic di-GMP (also called cyclic diguanylate and c-di-GMP) is a second messenger used in signal transduction in a wide variety of bacteria. [1] Cyclic di-GMP is not known to be used by archaea , and has only been observed in eukaryotes in Dictyostelium . [ 2 ]
Phosphodiesterase inhibitors prevent the degradation of cGMP, thereby enhancing and/or prolonging its effects. For example, Sildenafil (Viagra) and similar drugs enhance the vasodilatory effects of cGMP within the corpus cavernosum by inhibiting PDE 5 (or PDE V). This is used as a treatment for erectile dysfunction. However, the drug can ...
All PDE5 inhibitors are generally well tolerated. [1] The occurrence of side effects, or adverse drug reactions (ADRs), with PDE5 inhibitors depends on the dose and type of agent. [1] Headache is a very common ADR, occurring in >10% of patients. Other common ADRs include: dizziness, flushing, dyspepsia, nasal congestion or rhinitis. [6]
Phosphodiesterase-5. A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).
PDE5 inhibitors are generally well tolerated, with side effects including transient headaches, flushing, dyspepsia, congestion and dizziness. [3] There have also been reports of temporary vision disturbances with sildenafil and, to a lesser extent, vardenafil, and back and muscle pain with tadalafil. [3]
This list was created from the NCI Thesaurus This page was last edited on 9 February 2024, at 00:17 (UTC). Text ... List of phosphodiesterase inhibitors.
Cyclic-guanylate-specific phosphodiesterase (EC 3.1.4.52, cyclic bis(3′→5')diguanylate phosphodiesterase, c-di-GMP-specific phosphodiesterase, c-di-GMP phosphodiesterase, phosphodiesterase, phosphodiesterase A1, PDEA1, VieA) is an enzyme with systematic name cyclic bis(3′→5′)diguanylate 3-guanylylhydrolase.