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Lymph nodes may become enlarged in malignant disease. This cervical lymphadenopathy may be reactive or metastatic. [1] Alternatively, enlarged lymph nodes may represent a primary malignancy of the lymphatic system itself, such as lymphoma (both Hodgkin's and non-Hodgkin's), [6] lymphocytic leukemia, [1] Lymphadenopathy that lasts less than two weeks or more than one year with no progressive ...
Size, where lymphadenopathy in adults is often defined as a short axis of one or more lymph nodes is greater than 10mm. [29] By extent: Localized lymphadenopathy: due to localized spot of infection; e.g., an infected spot on the scalp will cause lymph nodes in the neck on that same side to swell up
About 95% of the scrofula cases in adults are caused by Mycobacterium tuberculosis, most often in immunocompromised patients (about 50% of cervical tuberculous lymphadenopathy). In immunocompetent children, scrofula is often caused by atypical mycobacteria ( Mycobacterium scrofulaceum ) and other nontuberculous mycobacteria (NTM).
However, the disorder can occur in adults. Furthermore, the disease in children or adults may progress to cause severe, extensive, and disfiguring skin lesions unrelated to sunlight exposure, facial edema, and systemic manifestations such as fever, weight loss, and enlargements of lymph nodes, liver, and/or spleen.
In the developing world, people are more often infected in early childhood when there are fewer symptoms. [13] In those between 16 and 20 it is the cause of about 8% of sore throats. [9] About 45 out of 100,000 people develop infectious mono each year in the United States. [5] Nearly 95% of people have had an EBV infection by the time they are ...
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Children often have generalized lymphadenopathy of the head and neck, or even PGL, without the finding of a sinister cause. At puberty this usually disappears. The immune system of some people may be sensitized by exposure to a living exogenous irritant such as a bacterial or viral infection , which then results in PGL after the organism has ...
Over 75% of all lymphadenopathies are observed as local, usually involving specifically the head and neck regions. [4] It has been estimated that patients who present lymphadenopathy has an estimated 1.1% chance of developing malignancy. [11] The rate of childhood malignancy associated with lymphadenopathy is low, however this increases with age.
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