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Gene regulatory pathway. In genetics, a regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. Regulatory sequences, which encode regulatory genes, are often at the five prime end (5') to the start site of transcription of the gene they regulate. In addition, these sequences ...
Cis-regulatory DNA sequences that are located in DNA regions distant from the promoters of genes can have very large effects on gene expression, with some genes undergoing up to 100-fold increased expression due to such a cis-regulatory sequence. [3] These cis-regulatory sequences include enhancers, silencers, insulators and tethering elements. [4]
21384 Ensembl ENSG00000092607 ENSMUSG00000027868 UniProt Q96SF7 O70306 RefSeq (mRNA) NM_152380 NM_001330677 NM_009323 RefSeq (protein) NP_001317606 NP_689593 NP_033349 Location (UCSC) Chr 1: 118.88 – 118.99 Mb Chr 3: 99.15 – 99.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse T-box transcription factor TBX15 is protein that is encoded in humans by the Tbx15 gene, mapped to ...
Regulation of gene expression, or gene regulation, [1] includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental ...
In humans, the DMD gene is located on the short (p) arm of the X chromosome between positions 21.2 and 21.1. Dystrophin is a rod-shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane.
In humans, the MSTN gene is located on the long (q) arm of chromosome 2 at position 32.2. [5] Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. [6] Myostatin is a myokine that is produced and released by myocytes and acts on muscle cells to inhibit muscle growth. [7]
Structure of a gene regulatory network Control process of a gene regulatory network. A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell.
The gene was first reported by two independent research groups Aaltonen et al. and Nagamine et al. in 1997 who were able to isolate and clone the gene from human chromosome 21q22.3. Their work was able to show that mutations in the AIRE gene are responsible for the pathogenesis of Autoimmune polyglandular syndrome type I. [ 5 ] [ 8 ] More ...