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The notochord is an elastic, rod-like structure found in chordates. In chordate vertebrates the notochord is an embryonic structure that disintegrates, as the vertebrae develop, to become the nucleus pulposus in the intervertebral discs of the vertebral column.
[17] [13] TBXT transcribes genes that form notochord cells, which are responsible for the flexibility, length, and balance of the spine, including tail vertebrae. [18] Because of the role that the transcription factor plays in spinal development, it is cited as being the protein that is primarily responsible for tail development in mammals.
The lancelet notochord, unlike the vertebrate spine, extends into the head. This gives the subphylum, Cephalochordata, its name ( κεφαλή , kephalē means 'head'). The fine structure of the notochord and the cellular basis of its adult growth are best known for the Bahamas lancelet, Asymmetron lucayanum [ 51 ]
As some lineages of the 90% of species that lack a backbone or notochord might have lost these structures over time, this complicates the classification of chordates. Some chordate lineages may only be found by DNA analysis, when there is no physical trace of any chordate-like structures. [41]
Homeobox protein notochord (NOTO) is a transcription factor [1] encoded by the gene notochord homeobox (NOTO) located on the short arm of chromosome 2 (2p13.2) in humans (Homo sapiens). [2] An ortholog of NOTO is found in the house mouse ( Mus musculus ), among other species, as the gene notochord homeobox ( Noto ) located on chromosome 6 ...
This forms the notochord, which induces the formation of the neural tube, and establishes the anterior-posterior body axis. The notochord extends beneath the neural tube from the head to the tail. The mesoderm moves to the midline until it covers the notochord. When the mesoderm cells proliferate, they form the paraxial mesoderm.
The SHH gene is a member of the hedgehog gene family with five variations of DNA sequence alterations or splice variants. [37] SHH is located on chromosome seven and initiates the production of Sonic Hedgehog protein. [37] This protein sends short- and long-range signals to embryonic tissues to regulate development. [38]
In eukaryotes, DNA is located in the cell nucleus, with small amounts in mitochondria and chloroplasts. In prokaryotes, the DNA is held within an irregularly shaped body in the cytoplasm called the nucleoid. [97] The genetic information in a genome is held within genes, and the complete set of this information in an organism is called its genotype.