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Marker ski bindings from the 1990s to 2000s. In 2007, Marker unveiled a new freeski binding system called the Duke. Complemented by the Jester, the new system redefined the performance parameters for freeride bindings. In 2008, the company released two new bindings, the Baron and the Griffon, that are also based on the Duke system.
The first modern heel-and-toe binding for alpine skiing was the Cubco binding, first introduced in 1950 but not popular until about 1960. A heel-release binding faced the problem that there was no obvious place to attach to on the heel, so the Cubco solved this by screwing small metal clips into the sole of the boot.
This high specificity, combined with the presence of CD3 at all stages of T-cell development, makes it a useful immunohistochemical marker for T cells in tissue sections. The antigen remains present in almost all T-cell lymphomas and leukaemias , and can therefore be used to distinguish them from superficially similar B-cell and myeloid neoplasms .
CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections. The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms.
CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed. In humans, the gene is located on the long arm of chromosome 11 . There is no confirmed ligand for CD5 but there is evidence that CD72, a C-type lectin, may be a ligand or that CD5 may be homophilic, binding CD5 on the surface of other cells. [ 6 ]
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Although Maxam and Gilbert published their chemical sequencing method two years after Frederick Sanger and Alan Coulson published their work on plus-minus sequencing, [2] [3] Maxam–Gilbert sequencing rapidly became more popular, since purified DNA could be used directly, while the initial Sanger method required that each read start be cloned for production of single-stranded DNA.
Documents containing Adobe extended features still carry the PDF base version number 1.7 but also contain an indication of which extension was followed during document creation. [21] PDF documents conforming to ISO 32000-2 carry the PDF version number 2.0, and are known to developers as "PDF 2.0 documents".