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Solifenacin, sold as the brand name Vesicare [a] among others, is a medicine used to treat overactive bladder and neurogenic detrusor overactivity (NDO). [1] [2] It may help with incontinence, urinary frequency, and urinary urgency. [3] Benefits appear similar to other medications in the class. [4] It is taken by mouth. [1]
Darifenacin (trade name Enablex in United States and Canada, Emselex in the European Union) is a medication used to treat urinary incontinence due to an overactive bladder. [1] [2] [3] It was discovered by scientists at the Pfizer research site in Sandwich, UK under the identifier UK-88,525 and used to be marketed by Novartis.
From or to a drug trade name: This is a redirect from (or to) the trade name of a drug to (or from) the international nonproprietary name (INN).
Overactive bladder (OAB) is a common condition where there is a frequent feeling of needing to urinate to a degree that it negatively affects a person's life. [2] The frequent need to urinate may occur during the day, at night , or both. [ 4 ]
Symptoms include overactive bladder, urinary urgency, frequency, incontinence or difficulty passing urine. [3] A range of diseases or conditions can cause neurogenic bladder including spinal cord injury , multiple sclerosis , stroke , brain injury, spina bifida , peripheral nerve damage, Parkinson's disease , multiple system atrophy or other ...
A 2023 systematic review by Funada et al. evaluated the effectiveness of bladder training in treating overactive bladder compared to anticholinergic medications and no treatment. The review found that: Bladder training significantly improved urinary symptoms, including reducing frequency and urgency episodes. [2]
An overactive bladder can often cause urinary incontinence. Though both urinary frequency and volumes have been shown to have a circadian rhythm, meaning day and night cycles, [29] it is not entirely clear how these are disturbed in the overactive bladder. Urodynamic testing can help to explain the symptoms.
The bladder also contains β 3 adrenergic receptors, and pharmacological agonists of this receptor are used to treat overactive bladder. The mucosa of the urinary bladder may herniate through the detrusor muscle. [6] This is most often an acquired condition due to high pressure in the urinary bladder, damage, or existing connective tissue ...